Reactions
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These reactions approximate the behaviour of the Wnt pathway and include reaction rules for the components Axin, phosphorylated Axin (AxinP), beta-catenin (BetaCat), and activated receptor (Rec) (see SBML).
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- BetaCat + AxinP ↔ BetaCatAxinP, beta = 1.0, rel = 0.1
- BetaCatAxinP → AxinP, deg = 0.5
- Ø → BetaCat, bsyn = 0.00423
- BetaCat → Ø, BetaCatAxinP → AxinP, bdeg = 0.001
- BetaCat → BetaCat + Axin, asyn = 0.012
- Axin → Ø, AxinP → Ø, BetaCatAxinP → Ø, adeg = 0.00167
- Axin ↔ AxinP, phos = 0.1, dephos = 0.05
- Rec + AxinP ↔ RecAxinP, wnt = 300, wrel = 0.01
- RecAxinP → Rec, internal = 0.008
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Model simulations
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At low stimulus |
Stochastic | Deterministic |
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At high stimulus |
Stochastic | Deterministic |
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