Wnt pathway map

Beta Beta Beta Beta Beta APC APC Axin Axin GSK GSK GSK TCF TCF Dsh Dsh Wnt
Pi-calculus model containing processes Beta, Axin and Rec (extended model with scaffold protein APC, kinase Gsk3, and receptors Fz and LRP)

Reactions

These reactions approximate the behaviour of the Wnt pathway and include reaction rules for the components Axin, phosphorylated Axin (AxinP), beta-catenin (BetaCat), and activated receptor (Rec) (see SBML).
  1. BetaCat + AxinP ↔ BetaCatAxinP, beta = 1.0, rel = 0.1
  2. BetaCatAxinP → AxinP, deg = 0.5
  3. Ø → BetaCat, bsyn = 0.00423
  4. BetaCat → Ø, BetaCatAxinP → AxinP, bdeg = 0.001
  5. BetaCat → BetaCat + Axin, asyn = 0.012
  6. Axin → Ø, AxinP → Ø, BetaCatAxinP → Ø, adeg = 0.00167
  7. Axin ↔ AxinP, phos = 0.1, dephos = 0.05
  8. Rec + AxinP ↔ RecAxinP, wnt = 300, wrel = 0.01
  9. RecAxinP → Rec, internal = 0.008

Model simulations

At low stimulus
StochasticDeterministic
At high stimulus
StochasticDeterministic